Regulation of Bach2 by the Aryl-hydrocarbon Receptor as a Mechanism for Suppression of B-cell Differentiation by 2,3,7,8-Tetrachlorodibenzo-p-dioxin

Exposure to the aryl hydrocarbon receptor (AHR) agonist, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), alters B cell differentiation and suppresses antibody production. Previous genomic studies in mouse B cells identified Bach2 as a direct target of the AHR. Bach2 is known to repress expression of Prd...

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Hauptverfasser: De Abrew, K. Nadira, Phadnis, Ashwini S., Crawford, Robert B., Kaminski, Norbert E., Thomas, Russell S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106294/
https://ncbi.nlm.nih.gov/pubmed/21296099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2011.01.020
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