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SHP-1 is Directly Activated by the Aryl Hydrocarbon Receptor and regulates BCL-6 in the presence of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
The environmental contaminant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), which is a strong AHR agonist, causes significant suppression of human B cell activation and differentiation. The current studies describe the identification of Src homology phosphatase 1 (SHP-1) encoded by the gene PTPN6 as a...
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| Publicado en: | Toxicol Appl Pharmacol |
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| Main Authors: | , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2016
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5064869/ https://ncbi.nlm.nih.gov/pubmed/27546522 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2016.08.014 |
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