Fine mapping and trans-ethnic genotyping establish IL2/IL21 genetic association with lupus and localize this genetic effect to IL21

OBJECTIVE: Genetic association of the IL2/IL21 region at 4q27 has been previously reported in lupus and a number of autoimmune and inflammatory diseases. Herein, using a very large cohort of lupus patients and controls, we localize this genetic effect to the IL21 gene. METHODS: We genotyped 45 tag S...

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Autors principals: Hughes, Travis, Kim-Howard, Xana, Kelly, Jennifer A., Kaufman, Kenneth M., Langefeld, Carl D., Ziegler, Julie, Sanchez, Elena, Kimberly, Robert P., Edberg, Jeffrey C., Ramsey-Goldman, Rosalind, Petri, Michelle, Reveille, John D., Martin, Javier, Brown, Elizabeth E., Vilá, Luis M., Alarcón, Graciela S., James, Judith A., Gilkeson, Gary S., Moser, Kathy L., Gaffney, Patrick M., Merrill, Joan T., Vyse, Timothy J., Alarcón-Riquelme, Marta E., Nath, Swapan K., Harley, John B., Sawalha, Amr H.
Format: Artigo
Idioma:Inglês
Publicat: 2011
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106139/
https://ncbi.nlm.nih.gov/pubmed/21425124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.30320
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