Analysis of autosomal genes reveals gene–sex interactions and higher total genetic risk in men with systemic lupus erythematosus

OBJECTIVES: Systemic lupus erythematosus (SLE) is a sexually dimorphic autoimmune disease which is more common in women, but affected men often experience a more severe disease. The genetic basis of sexual dimorphism in SLE is not clearly defined. A study was undertaken to examine sex-specific genet...

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Hlavní autoři: Hughes, Travis, Adler, Adam, Merrill, Joan T, Kelly, Jennifer A, Kaufman, Kenneth M, Williams, Adrienne, Langefeld, Carl D, Gilkeson, Gary S, Sanchez, Elena, Martin, Javier, Boackle, Susan A, Stevens, Anne M, Alarcón, Graciela S, Niewold, Timothy B, Brown, Elizabeth E, Kimberly, Robert P, Edberg, Jeffrey C, Ramsey-Goldman, Rosalind, Petri, Michelle, Reveille, John D, Criswell, Lindsey A, Vilá, Luis M, Jacob, Chaim O, Gaffney, Patrick M, Moser, Kathy L, Vyse, Timothy J, Alarcón-Riquelme, Marta E, James, Judith A, Tsao, Betty P, Scofield, R Hal, Harley, John B, Richardson, Bruce C, Sawalha, Amr H
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3324666/
https://ncbi.nlm.nih.gov/pubmed/22110124
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/annrheumdis-2011-200385
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