Antisense and Antigene Inhibition of Gene Expression by Cell-Permeable Oligonucleotide-Oligospermine Conjugates

Oligonucleotides and their derivatives are a proven chemical strategy for modulating gene expression. However, their negative charge remains a challenge for delivery and target recognition inside cells. Here we show that oligonucleotide-oligospermine conjugates (Zip nucleic acids or ZNAs) can help o...

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Detaylı Bibliyografya
Asıl Yazarlar: Gagnon, Keith T., Watts, Jonathan K., Pendergraff, Hannah M., Montaillier, Christophe, Thai, Danielle, Potier, Pierre, Corey, David R.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3106116/
https://ncbi.nlm.nih.gov/pubmed/21539318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja200312y
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