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Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Telithromycin
[Image: see text] There is an urgent need to discover new drugs to address the pressing problem of antibiotic resistance. Macrolide antibiotics such as erythromycin (1) are safe, broad-spectrum antibiotics used in the clinic since 1954. Herein, we report the synthesis and evaluation of 4,8,10-trides...
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| Hlavní autoři: | , , , , , , |
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| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
American Chemical Society
2010
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| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3105755/ https://ncbi.nlm.nih.gov/pubmed/21643527 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1002184 |
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