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Desmethyl Macrolides: Synthesis and Evaluation of 4,8,10-Tridesmethyl Telithromycin

[Image: see text] There is an urgent need to discover new drugs to address the pressing problem of antibiotic resistance. Macrolide antibiotics such as erythromycin (1) are safe, broad-spectrum antibiotics used in the clinic since 1954. Herein, we report the synthesis and evaluation of 4,8,10-trides...

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Autors principals: Velvadapu, Venkata, Paul, Tapas, Wagh, Bharat, Klepacki, Dorota, Guvench, Olgun, MacKerell, Alexander, Andrade, Rodrigo B.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2010
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105755/
https://ncbi.nlm.nih.gov/pubmed/21643527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml1002184
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