Desmethyl Macrolides: Synthesis and Evaluation of 4-Desmethyl Telithromycin

[Image: see text] Novel sources of antibiotics are needed to address the serious threat of bacterial resistance. Accordingly, we have launched a structure-based drug design program featuring a desmethylation strategy wherein methyl groups have been replaced with hydrogens. Herein we report the total...

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Bibliografiske detaljer
Main Authors: Glassford, Ian, Lee, Miseon, Wagh, Bharat, Velvadapu, Venkata, Paul, Tapas, Sandelin, Gary, DeBrosse, Charles, Klepacki, Dorota, Small, Meagan C., MacKerell, Alexander D., Andrade, Rodrigo B.
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2014
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4160760/
https://ncbi.nlm.nih.gov/pubmed/25221660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml5002097
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