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Desmethyl Macrolides: Synthesis and Evaluation of 4,8-Didesmethyl Telithromycin
[Image: see text] There is an urgent need for novel sources of antibiotics to address the incessant and inevitable onset of bacterial resistance. To this end, we have initiated a structure-based drug design program that features a desmethylation strategy (i.e., replacing methyl groups with hydrogens...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American
Chemical Society
2012
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3763958/ https://ncbi.nlm.nih.gov/pubmed/24015325 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml300230h |
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