Enhancement of the cleavage rates of DNA-armed hammerhead ribozymes by various divalent metal ions.

In order to characterize structure-function relationships, the kinetic behavior of chimeric RNA/DNA ribozyme was compared with that of all RNA ribozyme. Determined kcat values were proven to represent the chemical-cleavage step and not the product-dissociation step. In agreement with the finding by...

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Veröffentlicht in:	Nucleic Acids Res
Hauptverfasser:	Sawata, S, Shimayama, T, Komiyama, M, Kumar, P K, Nishikawa, S, Taira, K
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Oxford University Press 1993
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310531/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7506830/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.24.5656
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