Post-injury Administration of NAAG Peptidase Inhibitor Prodrug, PGI-02776, in Experimental TBI

Traumatic brain injury (TBI) leads to a rapid and excessive increase in glutamate concentration in the extracellular milieu, which is strongly associated with excitotoxicity and neuronal degeneration. N-acetylaspartylglutamate (NAAG), a prevalent peptide neurotransmitter in the vertebrate nervous sy...

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Main Authors: Feng, Jun-Feng, Van, Ken C., Gurkoff, Gene G., Kopriva, Christina, Olszewski, Rafal T., Song, Minsoo, Sun, Shifeng, Xu, Man, Neale, Joseph H., Yuen, Po-Wai, Lowe, David A., Zhou, Jia, Lyeth, Bruce G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3105192/
https://ncbi.nlm.nih.gov/pubmed/21565332
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2011.04.022
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