Engagement of S1P(1)-degradative mechanisms leads to vascular leak in mice

GPCR inhibitors are highly prevalent in modern therapeutics. However, interference with complex GPCR regulatory mechanisms leads to both therapeutic efficacy and adverse effects. Recently, the sphingosine-1-phosphate (S1P) receptor inhibitor FTY720 (also known as Fingolimod), which induces lymphopen...

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Bibliografiska uppgifter
Huvudupphovsmän: Oo, Myat Lin, Chang, Sung-Hee, Thangada, Shobha, Wu, Ming-Tao, Rezaul, Karim, Blaho, Victoria, Hwang, Sun-Il, Han, David K., Hla, Timothy
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2011
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104755/
https://ncbi.nlm.nih.gov/pubmed/21555855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI45403
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