Differences in the accessibility of methylated and unmethylated DNA to DNase I.
DNase I binds in the minor groove of DNA and is used as an enzymatic tool to investigate the interaction of proteins with DNA. Here we show that the major groove located 5-methyldeoxycytidine can enhance or inhibit the cleavage rates of DNA by DNase I. This effect may be caused in part by changes in...
Gardado en:
| Publicado en: | Nucleic Acids Res |
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| Principais autores: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Oxford University Press
1993
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| Acceso en liña: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC310463/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8290342/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/21.25.5843 |
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