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Differences in the accessibility of methylated and unmethylated DNA to DNase I.
DNase I binds in the minor groove of DNA and is used as an enzymatic tool to investigate the interaction of proteins with DNA. Here we show that the major groove located 5-methyldeoxycytidine can enhance or inhibit the cleavage rates of DNA by DNase I. This effect may be caused in part by changes in...
保存先:
| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
1993
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| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC310463/ https://ncbi.nlm.nih.gov/pubmed/8290342 |
| タグ: |
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