Hepatocyte-specific Hypoxia Inducible Factor-1α is a determinant of lipid accumulation and liver injury in alcohol-induced steatosis in mice

Chronic alcohol causes hepatic steatosis and liver hypoxia. Hypoxia-regulated Hypoxia-inducible factor 1-α, (HIF1α) may regulate liporegulatory genes but the relationship of HIF1 to steatosis remains unknown. We investigated HIF1α in alcohol-induced hepatic lipid accumulation. Alcohol administration...

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Main Authors: Nath, Bharath, Levin, Ivan, Csak, Timea, Petrasek, Jan, Mueller, Christian, Kodys, Karen, Catalano, Donna, Mandrekar, Pranoti, Szabo, Gyongyi
Format: Artigo
Language:Inglês
Published: 2011
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104403/
https://ncbi.nlm.nih.gov/pubmed/21520168
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24256
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