Interferon regulatory factor 3 and Type I interferons are protective in alcoholic liver injury in mice via cross-talk of parenchymal and myeloid cells

Alcoholic liver disease (ALD) features increased hepatic exposure to bacterial lipopolysaccharide (LPS). Toll-like receptor-4 (TLR4) recognizes LPS and activates signaling pathways depending on MyD88 or TRIF adaptors. We previously showed that MyD88 is dispensable in ALD. TLR4 induces Type-I interfe...

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Autori principali: Petrasek, Jan, Dolganiuc, Angela, Csak, Timea, Nath, Bharath, Hritz, Istvan, Kodys, Karen, Catalano, Donna, Kurt-Jones, Evelyn, Mandrekar, Pranoti, Szabo, Gyongyi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3069538/
https://ncbi.nlm.nih.gov/pubmed/21274885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/hep.24059
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