Deficiency in myeloid differentiation factor-2 and toll-like receptor 4 expression attenuates nonalcoholic steatohepatitis and fibrosis in mice

Toll-like receptor 4 (TLR4) and its coreceptor, myeloid differentiation factor-2 (MD-2), are key in recognition of lipopolysaccharide (LPS) and activation of proinflammatory pathways. Here we tested the hypothesis that TLR4 and its coreceptor MD-2 play a central role in nonalcoholic steatohepatitis...

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Detalhes bibliográficos
Main Authors: Csak, Timea, Velayudham, Arumugam, Hritz, Istvan, Petrasek, Jan, Levin, Ivan, Lippai, Dora, Catalano, Donna, Mandrekar, Pranoti, Dolganiuc, Angela, Kurt-Jones, Evelyn, Szabo, Gyongyi
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2011
Assuntos:
Liver and Biliary Tract
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3302188/
https://ncbi.nlm.nih.gov/pubmed/21233280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpgi.00163.2009
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