Detection of point mutations in human DNA by analysis of RNA conformation polymorphism(s).

RNA molecules were found to separate into numerous metastable conformational forms upon non-denaturing gel electrophoresis. The equilibration of the conformations was accelerated by heating or mild denaturing conditions. Single-base substitutions in the sequence of the RNAs caused changes in the con...

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Detalhes bibliográficos
Main Authors: Danenberg, P V, Horikoshi, T, Volkenandt, M, Danenberg, K, Lenz, H J, Shea, L C, Dicker, A P, Simoneau, A, Jones, P A, Bertino, J R
Formato: Artigo
Idioma:Inglês
Publicado em: 1992
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC310425/
https://ncbi.nlm.nih.gov/pubmed/1371351
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