Asymmetric Assembly of Merkel Cell Polyomavirus Large T-antigen Origin Binding Domains at the Viral Origin

The double-stranded DNA polyomavirus Merkel cell polyomavirus (MCV) causes Merkel cell carcinoma, an aggressive but rare human skin cancer that most often affects the immunosuppressed and elderly. As in other polyomaviruses, the large T-antigen of MCV recognizes the viral origin of replication by bi...

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Detalhes bibliográficos
Main Authors: Harrison, Celia J., Meinke, Gretchen, Kwun, Hyun Jin, Rogalin, Henry, Phelan, Paul J., Bullock, Peter A., Chang, Yuan, Moore, Patrick S., Bohm, Andrew
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104116/
https://ncbi.nlm.nih.gov/pubmed/21501625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2011.03.051
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