The Minimum Replication Origin of Merkel Cell Polyomavirus Has a Unique Large T-Antigen Loading Architecture and Requires Small T-Antigen Expression for Optimal Replication

Merkel cell polyomavirus (MCV) is a recently discovered human polyomavirus causing the majority of human Merkel cell carcinomas. We mapped a 71-bp minimal MCV replication core origin sufficient for initiating eukaryotic DNA replication in the presence of wild-type MCV large T protein (LT). The origi...

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Detalhes bibliográficos
Main Authors: Kwun, Hyun Jin, Guastafierro, Anna, Shuda, Masahiro, Meinke, Gretchen, Bohm, Andrew, Moore, Patrick S., Chang, Yuan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2786723/
https://ncbi.nlm.nih.gov/pubmed/19759150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01336-09
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