Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models

INTRODUCTION: Persistent STAT3 activation contributes to lung carcinogenesis. Survivin, one of STAT3-regulated genes, is antiapoptotic and confers cancer radioresistance. METHODS: We tested whether TG101209, a small-molecule inhibitor of JAK2 (a STAT3-activating tyrosine kinase), affected survivin e...

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Päätekijät: Sun, Yunguang, Moretti, Luigi, Giacalone, Nicholas J, Schleicher, Stephen, Speirs, Christina K., Carbone, David P., Lu, Bo
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2011
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC3104103/
https://ncbi.nlm.nih.gov/pubmed/21325979
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31820d9d11
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