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Inhibition of JAK2 Signaling by TG101209 Enhances Radiotherapy in Lung Cancer Models
INTRODUCTION: Persistent STAT3 activation contributes to lung carcinogenesis. Survivin, one of STAT3-regulated genes, is antiapoptotic and confers cancer radioresistance. METHODS: We tested whether TG101209, a small-molecule inhibitor of JAK2 (a STAT3-activating tyrosine kinase), affected survivin e...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3104103/ https://ncbi.nlm.nih.gov/pubmed/21325979 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/JTO.0b013e31820d9d11 |
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