Endoplasmic Reticulum Ca(2+) Release Modulates Endothelial Nitric-oxide Synthase via Extracellular Signal-regulated Kinase (ERK) 1/2-mediated Serine 635 Phosphorylation

Endothelial nitric-oxide synthase (eNOS) plays a central role in cardiovascular regulation. eNOS function is critically modulated by Ca(2+) and protein phosphorylation, but the interrelationship between intracellular Ca(2+) mobilization and eNOS phosphorylation is poorly understood. Here we show tha...

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Detalhes bibliográficos
Main Authors: Xiao, Zhihong, Wang, Tingting, Qin, Honghua, Huang, Chao, Feng, Youmei, Xia, Yong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103382/
https://ncbi.nlm.nih.gov/pubmed/21454579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.220236
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