The β-Arrestin Pathway-selective Type 1A Angiotensin Receptor (AT(1A)) Agonist [Sar(1),Ile(4),Ile(8)]Angiotensin II Regulates a Robust G Protein-independent Signaling Network

The angiotensin II peptide analog [Sar(1),Ile(4),Ile(8)]AngII (SII) is a biased AT(1A) receptor agonist that stimulates receptor phosphorylation, β-arrestin recruitment, receptor internalization, and β-arrestin-dependent ERK1/2 activation without activating heterotrimeric G-proteins. To determine th...

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Main Authors: Kendall, Ryan T., Strungs, Erik G., Rachidi, Saleh M., Lee, Mi-Hye, El-Shewy, Hesham M., Luttrell, Deirdre K., Janech, Michael G., Luttrell, Louis M.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103364/
https://ncbi.nlm.nih.gov/pubmed/21502318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.233080
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