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Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function
Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. Although it is well established that sclerostin is an osteocyte-secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated. We identified in tandem affinity purificatio...
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Artigo |
Idioma: | Inglês |
Publicado em: |
American Society for Biochemistry and Molecular Biology
2011
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Assuntos: | |
Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3103328/ https://ncbi.nlm.nih.gov/pubmed/21471202 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190330 |
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