Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. Although it is well established that sclerostin is an osteocyte-secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated. We identified in tandem affinity purificatio...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Leupin, Olivier, Piters, Elke, Halleux, Christine, Hu, Shouih, Kramer, Ina, Morvan, Frederic, Bouwmeester, Tewis, Schirle, Markus, Bueno-Lozano, Manuel, Ramos Fuentes, Feliciano J., Itin, Peter H., Boudin, Eveline, de Freitas, Fenna, Jennes, Karen, Brannetti, Barbara, Charara, Nadine, Ebersbach, Hilmar, Geisse, Sabine, Lu, Chris X., Bauer, Andreas, Van Hul, Wim, Kneissel, Michaela
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Biochemistry and Molecular Biology 2011
विषय:
Molecular Bases of Disease
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103328/
https://ncbi.nlm.nih.gov/pubmed/21471202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190330
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