Bone Overgrowth-associated Mutations in the LRP4 Gene Impair Sclerostin Facilitator Function

Humans lacking sclerostin display progressive bone overgrowth due to increased bone formation. Although it is well established that sclerostin is an osteocyte-secreted bone formation inhibitor, the underlying molecular mechanisms are not fully elucidated. We identified in tandem affinity purificatio...

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Main Authors: Leupin, Olivier, Piters, Elke, Halleux, Christine, Hu, Shouih, Kramer, Ina, Morvan, Frederic, Bouwmeester, Tewis, Schirle, Markus, Bueno-Lozano, Manuel, Ramos Fuentes, Feliciano J., Itin, Peter H., Boudin, Eveline, de Freitas, Fenna, Jennes, Karen, Brannetti, Barbara, Charara, Nadine, Ebersbach, Hilmar, Geisse, Sabine, Lu, Chris X., Bauer, Andreas, Van Hul, Wim, Kneissel, Michaela
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2011
Teme:
Molecular Bases of Disease
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3103328/
https://ncbi.nlm.nih.gov/pubmed/21471202
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.190330
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