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Doc2 supports spontaneous synaptic transmission by a Ca(2+)-independent mechanism

Two families of Ca(2+)-binding proteins have been proposed as Ca(2+)-sensors for spontaneous release: synaptotagmins and Doc2’s, with the intriguing possibility that Doc2’s may represent high-affinity Ca(2+)-sensors that are activated by deletion of synaptotagmins, thereby accounting for the increas...

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Autors principals: Pang, Zhiping P., Bacaj, Taulant, Yang, Xiaofei, Zhou, Peng, Xu, Wei, Südhof, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: 2011
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102832/
https://ncbi.nlm.nih.gov/pubmed/21521611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2011.03.011
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