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Syntaxin-1 N-peptide and H(abc)-domain perform distinct essential functions in synaptic vesicle fusion
Among SNARE proteins mediating synaptic vesicle fusion, syntaxin-1 uniquely includes an N-terminal peptide (‘N-peptide’) that binds to Munc18-1, and a large, conserved H(abc)-domain that also binds to Munc18-1. Previous in vitro studies suggested that the syntaxin-1 N-peptide is functionally importa...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
European Molecular Biology Organization
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3545302/ https://ncbi.nlm.nih.gov/pubmed/23188083 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2012.307 |
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