Conformational Switch of Syntaxin-1 Controls Synaptic Vesicle Fusion

During synaptic vesicle fusion, the SNARE-protein syntaxin-1 exhibits two conformations that both bind to Munc18-1: a ‘closed’ conformation outside the SNARE-complex, and an ‘open’ conformation in the SNARE-complex. Whereas SNARE-complexes containing ‘open’ syntaxin-1 and Munc18-1 are essential for...

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Autors principals: Gerber, Stefan H., Rah, Jong-Cheol, Min, Sang-Won, Liu, Xinran, de Wit, Heidi, Dulubova, Irina, Meyer, Alexander C., Rizo, Josep, Arancillo, Marife, Hammer, Robert E., Verhage, Matthijs, Rosenmund, Christian, Südhof, Thomas C.
Format: Artigo
Idioma:Inglês
Publicat: 2008
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3235364/
https://ncbi.nlm.nih.gov/pubmed/18703708
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1163174
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