Pharmacokinetics and Disposition of a Localized Lymphatic Polymeric Hyaluronan Conjugate of Cisplatin in Rodents

Cisplatin (CDDP) is an effective anticancer agent for many solid tumors but has significant systemic toxicity limiting its use in many patients. We have designed a loco-regional delivery system to increase platinum levels in the lymphatics, where early metastasis is most likely to occur, while reduc...

Full description

Saved in:
Bibliographic Details
Main Authors: Cai, Shuang, Xie, Yumei, Davies, Neal M., Cohen, Mark S., Forrest, M. Laird
Format: Artigo
Language:Inglês
Published: 2010
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102643/
https://ncbi.nlm.nih.gov/pubmed/19960530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.22016
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items