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In Silico Screening for PTPN22 Inhibitors: Active Hits From an Inactive Phosphatase Conformation
A gain-of-function mutant of the lymphoid phosphatase Lyp (PTPN22) has recently been implicated with type 1 diabetes and other autoimmune diseases, suggesting that small-molecule inhibitors of Lyp could be useful for the treatment of autoimmunity. Virtual ligand screening (VLS) was applied in the se...
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| 主要な著者: | , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2009
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3102533/ https://ncbi.nlm.nih.gov/pubmed/19177473 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cmdc.200800375 |
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