Llwytho...
Assessing Cellular Target Engagement by SHP2 (PTPN11) Phosphatase Inhibitors
The Src-homology 2 (SH2) domain-containing phosphatase 2 (SHP2), encoded by the PTPN11 proto-oncogene, is a key mediator of receptor tyrosine kinase (RTK)-driven cell signaling, promoting cell survival and proliferation. In addition, SHP2 is recruited by immune check point receptors to inhibit B and...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | J Vis Exp |
|---|---|
| Prif Awduron: | , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
2020
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8080703/ https://ncbi.nlm.nih.gov/pubmed/32744526 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3791/61457 |
| Tagiau: |
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