Crystal structures of the free and inhibited forms of plasmepsin I (PMI) from Plasmodium falciparum

Plasmepsin I (PMI) is one of the four vacuolar pepsin-like proteases responsible for hemoglobin degradation by the malarial parasite Plasmodium falciparum, and the only one with no crystal structure reported to date. Due to substantial functional redundancy of these enzymes, lack of inhibition of ev...

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Autori principali: Bhaumik, Prasenjit, Horimoto, Yasumi, Xiao, Huogen, Miura, Takuya, Hidaka, Koushi, Kiso, Yoshiaki, Wlodawer, Alexander, Yada, Rickey Y., Gustchina, Alla
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3102120/
https://ncbi.nlm.nih.gov/pubmed/21521654
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jsb.2011.04.009
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