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Structural insights into activation and inhibition of histo-aspartic protease (HAP) from Plasmodium falciparum
Histo-aspartic protease (HAP) from Plasmodium falciparum offers a promising target for the development of novel antimalarial drugs. HAP exhibits high sequence similarity to pepsin-like aspartic proteases, but one of the two catalytic aspartates, Asp32, is replaced by histidine. Crystal structures of...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2011
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3501826/ https://ncbi.nlm.nih.gov/pubmed/21928835 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi201118z |
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