Ras mutation cooperates with β-catenin activation to drive bladder tumourigenesis

Mutations in the Ras family of proteins (predominantly in H-Ras) occur in approximately 40% of urothelial cell carcinoma (UCC). However, relatively little is known about subsequent mutations/pathway alterations that allow tumour progression. Indeed, expressing mutant H-Ras within the mouse bladder d...

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Autors principals: Ahmad, I, Patel, R, Liu, Y, Singh, L B, Taketo, M M, Wu, X-R, Leung, H Y, Sansom, O J
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2011
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101820/
https://ncbi.nlm.nih.gov/pubmed/21368895
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.7
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