Protection of pancreatic INS-1 β-cells from glucose- and fructose-induced cell death by inhibiting mitochondrial permeability transition with cyclosporin A or metformin

Hyperglycemia is detrimental to β-cell viability, playing a major role in the progression of β-cell loss in diabetes mellitus. The permeability transition pore (PTP) is a mitochondrial channel involved in cell death. Recent evidence suggests that PTP inhibitors prevent hyperglycemia-induced cell dea...

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Detalhes bibliográficos
Main Authors: Lablanche, S, Cottet-Rousselle, C, Lamarche, F, Benhamou, P-Y, Halimi, S, Leverve, X, Fontaine, E
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101812/
https://ncbi.nlm.nih.gov/pubmed/21430707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.15
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