Cdc48/p97 and Shp1/p47 regulate autophagosome biogenesis in concert with ubiquitin-like Atg8

The molecular details of the biogenesis of double-membraned autophagosomes are poorly understood. We identify the Saccharomyces cerevisiae AAA–adenosine triphosphatase Cdc48 and its substrate-recruiting cofactor Shp1/Ubx1 as novel components needed for autophagosome biogenesis. In mammals, the Cdc48...

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Autors principals: Krick, Roswitha, Bremer, Sebastian, Welter, Evelyn, Schlotterhose, Petra, Muehe, Yvonne, Eskelinen, Eeva-Liisa, Thumm, Michael
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2010
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101598/
https://ncbi.nlm.nih.gov/pubmed/20855502
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201002075
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