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Structure of even/odd trinucleotide repeat sequences modulates persistence of non-B conformations and conversion to duplex

Expansion of trinucleotide repeats (TNR) has been implicated in the emergence of neurodegenerative diseases. Formation of non-B conformations such as hairpins by these repeat sequences during DNA replication and/or repair has been proposed as a contributing factor to expansion. In this work we emplo...

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Hlavní autoři: Figueroa, Amalia Ávila, Cattie, Douglas, Delaney, Sarah
Médium: Artigo
Jazyk:Inglês
Vydáno: 2011
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101280/
https://ncbi.nlm.nih.gov/pubmed/21526744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi200397b
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