Mitochondrial dysfunction in NnaD mutant flies and Purkinje cell degeneration (pcd) mice reveals a role for Nna proteins in neuronal bioenergetics

The Purkinje cell degeneration (pcd) mouse is a recessive model of neurodegeneration, involving cerebellum and retina. Purkinje cell death in pcd is dramatic, as >99% of Purkinje neurons are lost in three weeks. Loss-of-function of Nna1 causes pcd, and Nna1 is a highly conserved zinc carboxypepti...

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Detalhes bibliográficos
Main Authors: Chakrabarti, Lisa, Zahra, Rabaab, Jackson, Stephen M., Kazemi-Esfarjani, Parsa, Sopher, Bryce L., Mason, Amanda G., Toneff, Thomas, Ryu, Soyoung, Shaffer, Scott, Kansy, Janice W., Eng, Jeremiah, Merrihew, Gennifer, MacCoss, Michael J., Murphy, Anne, Goodlett, David R., Hook, Vivian, Bennett, Craig L., Pallanck, Leo, La Spada, Albert R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101252/
https://ncbi.nlm.nih.gov/pubmed/20620870
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2010.05.024
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