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CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice
A perplexing question in neurodegeneration is why different neurons degenerate. The Purkinje cell degeneration (pcd) mouse displays a dramatic phenotype of degeneration of cerebellar Purkinje cells. Loss of CCP1/Nna1 deglutamylation of tubulin accounts for pcd neurodegeneration, but the mechanism is...
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| Publicado no: | J Cell Biol |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Rockefeller University Press
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6314562/ https://ncbi.nlm.nih.gov/pubmed/30337352 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709028 |
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