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CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice

A perplexing question in neurodegeneration is why different neurons degenerate. The Purkinje cell degeneration (pcd) mouse displays a dramatic phenotype of degeneration of cerebellar Purkinje cells. Loss of CCP1/Nna1 deglutamylation of tubulin accounts for pcd neurodegeneration, but the mechanism is...

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Bibliografiske detaljer
Udgivet i:J Cell Biol
Main Authors: Gilmore-Hall, Stephen, Kuo, Jennifer, Ward, Jacqueline M., Zahra, Rabaab, Morrison, Richard S., Perkins, Guy, La Spada, Albert R.
Format: Artigo
Sprog:Inglês
Udgivet: Rockefeller University Press 2019
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6314562/
https://ncbi.nlm.nih.gov/pubmed/30337352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.201709028
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