Calbindin 2 (CALB2) Regulates 5-Fluorouracil Sensitivity in Colorectal Cancer by Modulating the Intrinsic Apoptotic Pathway

The role of the calcium binding protein, Calbindin 2 (CALB2), in regulating the response of colorectal cancer (CRC) cells to 5-Fluorouracil (5-FU) was investigated. Real-time RT-PCR and Western blot analysis revealed that CALB2 mRNA and protein expression were down-regulated in p53 wild-type and p53...

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Main Authors: Stevenson, Leanne, Allen, Wendy L., Proutski, Irina, Stewart, Gail, Johnston, Louise, McCloskey, Karen, Wilson, Peter M., Longley, Daniel B., Johnston, Patrick G.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2011
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3101240/
https://ncbi.nlm.nih.gov/pubmed/21629658
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0020276
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