Two distinct conformations of helix 6 observed in antagonist-bound structures of a β(1)-adrenergic receptor

The β(1)-adrenergic receptor (β(1)AR) is a G-protein-coupled receptor whose inactive state structure was determined using a thermostabilized mutant (β(1)AR–M23). However, it was not thought to be in a fully inactivated state because there was no salt bridge between Arg139 and Glu285 linking the cyto...

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Bibliografiska uppgifter
Huvudupphovsmän: Moukhametzianov, Rouslan, Warne, Tony, Edwards, Patricia C., Serrano-Vega, Maria J., Leslie, Andrew G. W., Tate, Christopher G., Schertler, Gebhard F. X.
Materialtyp: Artigo
Språk:Inglês
Publicerad: National Academy of Sciences 2011
Ämnen:
Biological Sciences
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100933/
https://ncbi.nlm.nih.gov/pubmed/21540331
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1100185108
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