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Suppression of Cytochrome P450 Reductase (POR) Expression in Hepatoma Cells Replicates the Hepatic Lipidosis Observed in Hepatic POR-Null Mice

Cytochrome P450 reductase (POR) is a microsomal electron transport protein essential to cytochrome P450-mediated drug metabolism and sterol and bile acid synthesis. The conditional deletion of hepatic POR gene expression in mice results in a marked decrease in plasma cholesterol levels counterbalanc...

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Bibliografiska uppgifter
Huvudupphovsmän: Porter, Todd D., Banerjee, Subhashis, Stolarczyk, Elzbieta I., Zou, Ling
Materialtyp: Artigo
Språk:Inglês
Publicerad: The American Society for Pharmacology and Experimental Therapeutics 2011
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100902/
https://ncbi.nlm.nih.gov/pubmed/21368239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.038562
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