O(6)-Methylguanine DNA Methyltransferase Deficiency and Response to Temozolomide-Based Therapy in Patients with Neuroendocrine Tumors

PURPOSE: Recent studies suggest that temozolomide has activity in neuroendocrine tumors. Low levels of the DNA repair enzyme, O(6)-methylguanine DNA methyltransferase (MGMT), are associated with sensitivity to temozolomide in other tumor types. We evaluated the prevalence of MGMT deficiency in neuro...

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Autors principals: Kulke, Matthew H., Hornick, Jason L., Frauenhoffer, Christine, Hooshmand, Susanne, Ryan, David P., Enzinger, Peter C., Meyerhardt, Jeffrey A., Clark, Jeffrey W., Stuart, Keith, Fuchs, Charles S., Redston, Mark S.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100724/
https://ncbi.nlm.nih.gov/pubmed/19118063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1078-0432.CCR-08-1476
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