Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

IL-15 uses the heterotrimeric receptor IL-2/IL-15Rβ and the γ chain shared with IL-2 and the cytokine-specific IL-15Rα. Although IL-15 shares actions with IL-2 that include activation of natural killer (NK) and CD8 T cells, IL-15 is not associated with capillary leak syndrome, activation-induced cel...

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書誌詳細
主要な著者: Waldmann, Thomas A., Lugli, Enrico, Roederer, Mario, Perera, Liyanage P., Smedley, Jeremy V., Macallister, Rhonda P., Goldman, Carolyn K., Bryant, Bonita R., Decker, Jean M., Fleisher, Thomas A., Lane, H. Clifford, Sneller, Michael C., Kurlander, Roger J., Kleiner, David E., Pletcher, John M., Figg, William D., Yovandich, Jason L., Creekmore, Stephen P.
フォーマット: Artigo
言語:Inglês
出版事項: American Society of Hematology 2011
主題:
Immunobiology
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100690/
https://ncbi.nlm.nih.gov/pubmed/21385847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311456
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