Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

IL-15 uses the heterotrimeric receptor IL-2/IL-15Rβ and the γ chain shared with IL-2 and the cytokine-specific IL-15Rα. Although IL-15 shares actions with IL-2 that include activation of natural killer (NK) and CD8 T cells, IL-15 is not associated with capillary leak syndrome, activation-induced cel...

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Hlavní autoři: Waldmann, Thomas A., Lugli, Enrico, Roederer, Mario, Perera, Liyanage P., Smedley, Jeremy V., Macallister, Rhonda P., Goldman, Carolyn K., Bryant, Bonita R., Decker, Jean M., Fleisher, Thomas A., Lane, H. Clifford, Sneller, Michael C., Kurlander, Roger J., Kleiner, David E., Pletcher, John M., Figg, William D., Yovandich, Jason L., Creekmore, Stephen P.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2011
Témata:
Immunobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100690/
https://ncbi.nlm.nih.gov/pubmed/21385847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311456
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