Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques

IL-15 uses the heterotrimeric receptor IL-2/IL-15Rβ and the γ chain shared with IL-2 and the cytokine-specific IL-15Rα. Although IL-15 shares actions with IL-2 that include activation of natural killer (NK) and CD8 T cells, IL-15 is not associated with capillary leak syndrome, activation-induced cel...

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Bibliografski detalji
Glavni autori: Waldmann, Thomas A., Lugli, Enrico, Roederer, Mario, Perera, Liyanage P., Smedley, Jeremy V., Macallister, Rhonda P., Goldman, Carolyn K., Bryant, Bonita R., Decker, Jean M., Fleisher, Thomas A., Lane, H. Clifford, Sneller, Michael C., Kurlander, Roger J., Kleiner, David E., Pletcher, John M., Figg, William D., Yovandich, Jason L., Creekmore, Stephen P.
Format: Artigo
Jezik:Inglês
Izdano: American Society of Hematology 2011
Teme:
Immunobiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100690/
https://ncbi.nlm.nih.gov/pubmed/21385847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-10-311456
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