IL-15 administered by continuous infusion to rhesus macaques induces massive expansion of CD8(+) T effector memory population in peripheral blood

IL-15 promotes activation and maintenance of natural killer (NK) and CD8(+) T effector memory (T(EM)) cells, making it a potential immunotherapeutic agent for the treatment of cancer and immunodeficiency states. Here we report the immunologic effects of 3 different IL-15 dosing strategies in Rhesus...

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Bibliographic Details
Main Authors: Sneller, Michael C., Kopp, William C., Engelke, Kory J., Yovandich, Jason L., Creekmore, Stephen P., Waldmann, Thomas A., Lane, H. Clifford
Format: Artigo
Language:Inglês
Published: American Society of Hematology 2011
Subjects:
Immunobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3245206/
https://ncbi.nlm.nih.gov/pubmed/22067383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2011-09-377804
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