PA28 and the proteasome immunosubunits play a central and independent role in the production of MHC class I-binding peptides in vivo

Proteasomes play a fundamental role in the processing of intracellular antigens into peptides that bind to MHC class I molecules for presentation to CD8 T cells. Three IFNγ-inducible catalytic proteasome (immuno)subunits as well as the IFNγ-inducible proteasome activator PA28 dramatically accelerate...

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Autores principales: de Graaf, Natascha, van Helden, Mary J. G., Textoris-Taube, Kathrin, Chiba, Tomoki, Topham, David J., Kloetzel, Peter-Michael, Zaiss, Dietmar M. W., Sijts, Alice J. A. M.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2011
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3100532/
https://ncbi.nlm.nih.gov/pubmed/21360704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201041040
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