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Pharmacological Inhibition of HDAC6 Attenuates Endothelial Barrier Dysfunction Induced by Thrombin
BACKGROUND: Endothelial barrier dysfunction (EBD) involves microtubule disassembly and enhanced cell contractility. Histone deacetylase 6 (HDAC6) deacetylates α-tubulin, and thereby destabilizes microtubules. This study investigates a role for HDAC6 in EBD. METHODS: EBD was induced with thrombin±HDA...
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| Glavni autori: | , , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2011
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3100403/ https://ncbi.nlm.nih.gov/pubmed/21531207 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.04.075 |
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