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Inhibition of Thrombin with PPACK-Nanoparticles Restores Disrupted Endothelial Barriers and Attenuates Thrombotic Risk in Experimental Atherosclerosis

OBJECTIVE: A role for thrombin in the pathogenesis of atherosclerosis has been suggested through clinical and experimental studies revealing a critical link between the coagulation system and inflammation. Although approved drugs for inhibition of thrombin and thrombin-related signaling have demonst...

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Bibliografski detalji
Izdano u:Arterioscler Thromb Vasc Biol
Glavni autori: Palekar, Rohun U., Jallouk, Andrew P., Myerson, Jacob W., Pan, Hua, Wickline, Samuel A.
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4767676/
https://ncbi.nlm.nih.gov/pubmed/26769047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306697
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